Endocrine Abstracts

Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes and obesity. We aimed to investigate spexin levels in lean type 1 diabetes patients and spexin’s role on glycemic parameters without the presence of obesity or insulin resistance.Patients and methods: This cross-sectional study included 29 type 1 diabetic patients and a control group of 23 healthy subjects adjusted for age, sex and body mass index (BM...

Objective: The finding of new biomarkers is needed to have an early diagnosis of breast cancer. In this study we evaluated serum levels of carboxylated osteocalcin (OC) and uncarboxylated osteocalcin(UcOC), CRP as a diagnostic biomarker for breast cancer.Design and methods: Blood samples of 39 women with newly diagnosed breast cancer with stage I were obtained before surgery and 39 age and BMI matched health women were selected as controls.<p class="...

Introduction: Metformin treatment was associated with decreased risk of various cancers including breast cancer. Exposure to sex steroid is related with increased risk of breast cancer. In this study, we aimed to evaluate the effect of metformin treatment on serum levels of sex steroids and sex hormone binding globulin (SHBG) in postmenopausal women with type 2 diabetes mellitus.Methods: Postmenopausal patients with newly diagnosed type 2 diabetes were r...

Aim: FGF-21, is a member of the FGF family that is involved in biological processes such as embryonic development, cellular growth, morphogenesis, tissue repair, tumor growth and invasion, with mitogenic and cellular vital activity activity in the cytogenetic localization of 19q13.33. Breast cancer is the fatal disease most commonly seen in women and increasing in frequency and the relationship between hormones secreted from adipose tissue and some cancers has been shown in re...